Human Sera
Cayman Chemical 7 12DImethylbenzanthrACn 100mg
An antibiotic active against veterinary isolates of C perfringens (MICs 0 06-0 5 mg/L) and B hyodysenteriae (MICs 12 5-100 g/ml) dietary administration reduces mortality in a broiler cockerel model of C perfringens infection at 15 and 30 ppm
Cayman Chemical MaprotIlInhydrochlorIde 50mg
A sugar sulfamate with anticonvulsant activity inhibits carbonic anhydrase from intact human erythrocytes (Ki ~200 M) as well as blocks sodium and calcium channels and kainite-induced currents in vitro increases GABAA receptor-mediated chloride ion flux inhibits hind-limb tonic-extensor seizures in the maximal electroshock seizure test in mice (ED50 39 mg/kg p.o.)
Cayman Chemical PF-04708671 50mg
A vitamin A metabolite and RAR ligand (IC50s 9 3 and 10 nM for RARa RARB and RARY respectively) induces expression of a luciferase reporter in COS-7 cells expressing RARa RARB or RARY (EC50s 169 9 and 2 nM respectively) reduces TPA-induced papilloma formation in mice at 17 nmol reduces bile duct proliferation hydroxyproline levels and liver inflammation in a rat model of a-naphthylisothiocyanate-induced chronic cholestasis reduces plasma levels of alkaline phosphatase and bile salts in the Mdr2-/- mouse model of cholestasis reduces hepatic fat accumulation triglycerides body weight and serum glucose levels in mice with Western diet-induced obesity
Cayman Chemical PF-03814735 50mg
A natural plant pigment which induces the release of nitric oxide by vascular endothelium causing vasorelaxation inhibits signaling through EGFRs suppressing the expression of ERa and inducing both apoptosis and autophagy at a dose of 1-40 M inhibits the HAT activities of p300/CBP (IC50 ~30 M)
Cayman Chemical GInkgolIde B 50mg
An amide form of niacin precursor in the synthesis of the metabolic cofactor NAD an inhibitor of SIRT1 (IC50 50 UM) increases SPT activity and the biosynthesis of ceramide glucosylceramide sphingomyelin free fatty acids and cholesterol in primary human keratinocytes at 10 UM induces apoptosis in SNU-398 SNU-739 and HepG2 cells at 40 UM prevents the formation of neoplastic lesions in a diethylnitrosamine-induced mouse model of HCC
Cayman Chemical MIldronatehydrate 100mg
An inhibitor of Hsp90 (IC50 erb82 and mutant p53 binds to and inhibits DNA topoisomerase type II proteins and GRP94
Cayman Chemical Meropenmhydrate 100mg
A substrate of the CYP450 isoform CYP2C19 also known as mephenytoin 4-hydroxylase can be used to screen for mutations in CYP2C19 by assaying its metabolites in urine
Cayman Chemical CortIcosteron 100mg
A potent synthetic CB with Ki values of 0.28 and 1.48 nM for the CB1 and CB2 receptors respectively intended for research and forensic applications
Cayman Chemical PF-04418948 100mg
PGB1 is a non-enzymatic dehydration product of PGE1 resulting from treatment with strong base. Oligomers of PGB1 are known to exhibit antioxidant and ionophoric activity.{8338341160}
Cayman Chemical D-LysIn lactam 50mg
A dual agonist of PPARa and PPARY binds to PPARa and PPARY (Kds 9 55 and 0 14 M respectively) increases transcriptional activity of PPARa and PPARY in a cell-based luciferase reporter assay at 10 M increases expression of PPARa PPARY and RXR as well as PPARa and PPARY target genes in HepG2 cells at 10 M increases glucose consumption as well as expression of GLUT2 and GLUT4 in HepG2 and 3T3-L1 cells respectively in a concentration-dependent manner decreases levels of glucose insulin free fatty acids triglycerides LDL ALT and AST in blood and reduces the size and number of hepatic lipid droplets in diabetic db/db mice at 20 mg/kg
Cayman Chemical D-OrnIthIn lactam 100mg
An antibiotic complex active against clinical isolates of S aureus S pyogenes S pneumoniae and S faecalis (MICs 0 016-2 Ug/ml) but not Gram-negative bacteria or C albicans (MICs 128 Ug/ml) inhibits cell wall synthesis in B subtilis at 0 5 Ug/ml effective against systemic S pyogenes S pneumoniae and S aureus infections in mice (ED50s 0 081 0 14 and 25 mg/kg per day respectively)
Cayman Chemical EchInacosIde 50mg
A peptide agonist of PAR1 and PAR2 activates PAR1 and PAR2 but not PAR3 or PAR4 does not induce thrombin signaling in COS-7 cells expressing PAR3 PAR4 or both receptors at 500 UM activates PAR1 and PAR2 in a cross-desensitization assay in Jurkat T cells at 500-1000 UM increases calcium levels in KNRK cells expressing rat or human PAR2 with a higher potency for rat PAR2