Human Sera
Cayman Chemical IsoguvacInhydrochlorIde 100mg
A GABAA; binds to rat synaptic cortical membranes (Ki = 55 nM); activates α1β2γ2S, α2β2γ2S, α3β2γ2S, α5β2γ2S, and ρ1 subunit-contanining GABAA receptors in a FLIPR assay (EC50s = 13, 4.5, 5.6, 0.78, and 3.1 µM, respectively); inhibits CA1 population spikes in rat hippocampal slices (EC50 = 13 µM); inhibits potassium/low magnesium-induced seizures in rat pups; chronic administration improves tactile over-reactivity, anxiety-like behaviors, and social impairments in mouse models of ASD at 2 mg/kg
Cayman Chemical LeupeptInhemIsulfate 50mg
A reversible inhibitor of cysteine, serine, and threonine proteases; inhibits cathepsin B (Ki = 6 nM), calpain (Ki = 10 nM), trypsin (Ki = 35 nM), plasmin (Ki = 3.4 μM), and kallikrein (Ki = 19 μM), and has no effect against chymotrypsin, elastase, renin, or pepsin
Cayman Chemical HydroflumethIazIde 50mg
A thiazide diuretic; inhibitor of carbonic anhydrase (CA); selective for CAII, VB, VII, IX, XII, and XIV (Kis = 305-235 nM) over CAI, IV, and VI (Kis = 2,840-8,250 nM) and CAIII, VA, and XIII (Kis = >10 µM)
Cayman Chemical Pralatrexate 100mg
A DHFR inhibitor (Ki = 13.4 pM) and antifolate; inhibits growth of acute lymphocytic leukemia cells (IC50 = 0.04 μM), MDA-468, SK-BR-3, and ZR-75-1 breast cancer cells (IC50s = 0.11, 0.28, and 0.26 μM, respectively), and SK-LC8 and SK-LC16 NSCLC cells (IC50s = 0.42 and 0.11 μM, respectively); increases median survival in vivo in an H9 T cell lymphoma mouse xenograft model
Cayman Chemical CyclopentolatehydroCLOrID 50mg
A muscarinic receptor antagonist (Kis = 1.62, 27.5, and 2.63 nM for M1, M2, and M3 receptors, respectively); inhibits carbachol-induced contraction of isolated human iris sphincter, circular ciliary muscle, and longitudinal ciliary muscle (Kbs = 7.9, 15.8, and 12.5 nM, respectively)
Cayman Chemical MetaramInoltartrate 50mg
A vasoconstrictor; increases cardiac output, mean arterial pressure, and coronary blood flow and decreases pulse rate in a canine model of cardiogenic shock when administered at a dose of 0.05 mg/kg; increases survival in a canine model of hemorrhagic hypotension; reverses acetoxycycloheximide-induced transient amnesia in a shock avoidance test in rats
Cayman Chemical Cabergoln 50mg
A potent and selective dopamine D2 receptor agonist (Kis = 0.912 and 6,935 nM for D2 and D1 receptors, respectively, in rat striatum); inhibits PRL secretion in and growth of rat pituitary tumor cells in a concentration-dependent manner; suppresses the mTOR signaling pathway in a time-dependent manner and induces autophagy and cell death in MMQ and GH3 rat pituitary cells; stimulates motor activity and decreases dyskinesias in a monkey model of MPTP-induced Parkinson's disease when administered at a dose of 0.25 mg/kg
Cayman Chemical RosIglItazonmaleate 100mg
A PPARγ agonist; activates PPARγ1 and PPARγ2 in reporter assays (EC50s = 30 and 100 nM, respectively); selectively activates chimeras containing the LBDs of PPARγ over PPARα and PPARδ in a cell-based reporter assay at 10 mM; an inhibitor of ACSL4 (IC50 = 0.5 µM), inhibits RSL3-induced ferroptosis in Pfa1 cells and Pparg KO cells, and increases survival in a Gpx4 KO mouse model of ferroptosis at 0.0125 mg/ml in the drinking water; decreases HbA1c and fasting blood glucose levels in a rat model of type 2 diabetes induced by STZ and a high-carbohydrate and high-fat diet at 4 mg/kg
Cayman Chemical 5-O-MethylvIsamIosIde 50mg
A chromone with diverse biological activities; inhibits the protein-protein interaction between histone H3 and 14-3-3ε and phosphorylation of histone H3, as well as induces cell cycle arrest at the G2/M phase, in HT-29 cells at 10 µM; inhibits compound 48/80-induced histamine release in LAD 2 mast cells from 10-100 µM; inhibits perivascular adventitia leukocyte infiltration and improves neurological deficits in a rat model of subarachnoid hemorrhage-induced vasospasm at 400 UG/kg; has been used as a quality control marker of S. diviaricata roots
Cayman Chemical Xylotetraose 50mg
A xylooligosaccharide; has been found in corn and various plant-based agricultural wastes
Cayman Chemical 2-CMethylgunosIn 50mg
An active metabolite of BMS-986094; inhibits replication in genotype 1b HCV replicon cells (EC50s = 5.2 and 3.2 µM in ELISA and luciferase assays, respectively); inhibits replication of the Zika virus clinical isolate ZIKVPE243 in HBMECs, SH-HY5Y cells, and Vero cells (EC50s = 0.88, 2.09, and 1.25 µM, respectively) but is toxic to newborn mice infected with ZIKVPE243 at postnatal day 2 at 25 mg/kg per day
Cayman Chemical 2OMethyl5methylurIdIn 100mg
A modified nucleoside; has been found in tRNA isolated from rabbit liver
Cayman Chemical 4-Alylcatechol 100mg
A phenol with diverse biological activities; scavenges DPPH radicals, reduces the formation of TBARS, and inhibits xanthine oxidase in cell-free assays (IC50s = 20.17, 2, and 16.7 µM, respectively); cytotoxic to HT-29 cells (IC50 = 30 UG/ml); reduces paw edema and arthritic paw tissue homogenate levels of IL-1β, PGE2, LTB4, and NO in a mouse model of steam-killed M. tuberculosis-induced arthritis at 4 mg/kg; has been used as a precursor in the synthesis of, and is a metabolite of, safrole
Cayman Chemical AcetohexamIde 100mg
A first generation sulfonylurea; inhibits SUR1-KIR6.2 (Kis = 22.9 and 14.2 µM, in HEK293 cells and rat brain, respectively); metabolized to the hypoglycemic compound L-hydroxyhexamide in vivo